Assay Detail
Binding
CHEMBL3829044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human p110beta expressed in baculovirus infected insect Sf9 cells incubated for 1 hr by ADP-gloreagen assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.37 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827894 | — | — | 1 | 7.47 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 7.27 |
| CHEMBL3828518 | — | — | 1 | - |
| CHEMBL3827814 | — | — | 1 | - |
| CHEMBL3827281 | — | — | 1 | - |
| CHEMBL3827517 | — | — | 1 | - |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827894 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3828518 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3827814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3827281 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3827517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483254 | PANOBINOSTAT | IC50 | > | 10000.0 | nM | - |