Assay Detail
Binding
CHEMBL3829339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human matriptase using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of bisbenzamidines as inhibitors for matriptase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.16 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269032 | — | — | 1 | 6.40 |
| CHEMBL3828410 | — | — | 1 | 6.31 |
| CHEMBL3594083 | — | — | 1 | 6.28 |
| CHEMBL3594082 | — | — | 1 | 6.25 |
| CHEMBL9126 | — | — | 1 | 6.14 |
| CHEMBL365916 | — | — | 1 | 6.09 |
| CHEMBL181480 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269032 | — | Ki | = | 397.0 | nM | 6.40 |
| CHEMBL3828410 | — | Ki | = | 492.0 | nM | 6.31 |
| CHEMBL3594083 | — | Ki | = | 526.0 | nM | 6.28 |
| CHEMBL3594082 | — | Ki | = | 558.0 | nM | 6.25 |
| CHEMBL9126 | — | Ki | = | 719.0 | nM | 6.14 |
| CHEMBL365916 | — | Ki | = | 816.0 | nM | 6.09 |
| CHEMBL181480 | — | Ki | = | 2280.0 | nM | 5.64 |