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Assay Detail

CHEMBL3829633

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human ATX using lysophosphatidylcholine as substrate by choline release assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Autotaxin (CHEMBL3691)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
Castagna D, Budd DC, Macdonald SJ, Jamieson C, Watson AJ.
J Med Chem (2016) 59 : 5604 -5621
PubMed 26745766 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.88 6.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3828074 ZIRITAXESTAT 3.0 1 6.88

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3828074 ZIRITAXESTAT IC50 = 131.0 nM 6.88