Assay Detail
Binding
CHEMBL3829805
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Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of bisbenzamidines as inhibitors for matriptase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.46 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9126 | — | — | 1 | 5.94 |
| CHEMBL3594083 | — | — | 1 | 5.79 |
| CHEMBL3594082 | — | — | 1 | 5.43 |
| CHEMBL269032 | — | — | 1 | 5.36 |
| CHEMBL181480 | — | — | 1 | 5.28 |
| CHEMBL365916 | — | — | 1 | 5.24 |
| CHEMBL3828410 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9126 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL3594083 | — | Ki | = | 1640.0 | nM | 5.79 |
| CHEMBL3594082 | — | Ki | = | 3680.0 | nM | 5.43 |
| CHEMBL269032 | — | Ki | = | 4390.0 | nM | 5.36 |
| CHEMBL181480 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL365916 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL3828410 | — | Ki | = | 6230.0 | nM | 5.21 |