Assay Detail
Binding
CHEMBL3829834
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Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.62 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827288 | — | — | 1 | 9.57 |
| CHEMBL3827610 | — | — | 1 | 9.55 |
| CHEMBL3827044 | — | — | 1 | 9.28 |
| CHEMBL128390 | — | — | 1 | 9.16 |
| CHEMBL3828693 | — | — | 1 | 9.10 |
| CHEMBL440526 | — | — | 1 | 8.87 |
| CHEMBL3828696 | — | — | 1 | 7.80 |
| CHEMBL3828443 | — | — | 1 | 7.15 |
| CHEMBL3827284 | — | — | 1 | 7.11 |
| CHEMBL3826998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827288 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3827610 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL3827044 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL128390 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL3828693 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL440526 | — | IC50 | = | 1.36 | nM | 8.87 |
| CHEMBL3828696 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL3828443 | — | IC50 | = | 71.2 | nM | 7.15 |
| CHEMBL3827284 | — | IC50 | = | 78.2 | nM | 7.11 |
| CHEMBL3826998 | — | IC50 | = | 122000.0 | nM | - |