Assay Detail
Binding
CHEMBL3830264
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Inhibition of c-MET (unknown origin) by caliper mobility shift assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.17 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828090 | — | — | 1 | 5.58 |
| CHEMBL3827777 | — | — | 1 | 5.44 |
| CHEMBL3827656 | — | — | 1 | 5.40 |
| CHEMBL3827230 | — | — | 1 | 5.31 |
| CHEMBL3828522 | — | — | 1 | 5.17 |
| CHEMBL3828375 | — | — | 1 | 5.12 |
| CHEMBL443681 | OBLONGIFOLIN C | — | 1 | 5.11 |
| CHEMBL3827525 | — | — | 1 | 4.93 |
| CHEMBL3828445 | — | — | 1 | 4.92 |
| CHEMBL3828170 | — | — | 1 | 4.72 |
| CHEMBL3828225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828090 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3827777 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL3827656 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL3827230 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL3828522 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL3828375 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL443681 | OBLONGIFOLIN C | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL3827525 | — | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL3828445 | — | IC50 | = | 11990.0 | nM | 4.92 |
| CHEMBL3828170 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3828225 | — | IC50 | > | 20000.0 | nM | - |