Assay Detail
Binding
CHEMBL3830762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fatty acid-binding protein, adipocyte (CHEMBL2083) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.77 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247920 | — | — | 1 | 6.66 |
| CHEMBL3828508 | — | — | 1 | 6.54 |
| CHEMBL3827483 | — | — | 1 | 6.42 |
| CHEMBL3827900 | — | — | 1 | 6.21 |
| CHEMBL3828043 | — | — | 1 | 6.16 |
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | 5.82 |
| CHEMBL1564699 | — | — | 1 | 5.64 |
| CHEMBL3827461 | — | — | 1 | 5.60 |
| CHEMBL3827833 | — | — | 1 | 5.51 |
| CHEMBL3827401 | — | — | 1 | 5.44 |
| CHEMBL3828660 | — | — | 1 | 5.37 |
| CHEMBL3827527 | — | — | 1 | 5.27 |
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | 5.17 |
| CHEMBL3827693 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247920 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3828508 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3827483 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL3827900 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL3828043 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL8659 | OLEIC ACID | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1564699 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3827461 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL3827833 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL3827401 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL3828660 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL3827527 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL267476 | LINOLEIC ACID | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL3827693 | — | Ki | = | 10300.0 | nM | 4.99 |