Assay Detail
Binding
CHEMBL3830925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Time-dependent inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-activating factor acetylhydrolase IB subunit alpha2 (CHEMBL4463) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.13 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827161 | — | — | 1 | 5.52 |
| CHEMBL3827906 | — | — | 1 | 5.40 |
| CHEMBL3827685 | — | — | 1 | 5.40 |
| CHEMBL3828611 | — | — | 1 | 5.30 |
| CHEMBL3827226 | — | — | 1 | 5.22 |
| CHEMBL3828744 | — | — | 1 | 5.00 |
| CHEMBL3827742 | — | — | 1 | 4.80 |
| CHEMBL3828121 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827161 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3827906 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3827685 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3828611 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3827226 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3828744 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3827742 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3828121 | — | IC50 | = | 38000.0 | nM | 4.42 |