Assay Detail
Binding
CHEMBL3830977
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Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortical membranes
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.64 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827598 | — | — | 1 | 7.25 |
| CHEMBL3827074 | — | — | 1 | 7.14 |
| CHEMBL3827331 | — | — | 1 | 7.10 |
| CHEMBL3827201 | — | — | 1 | 6.90 |
| CHEMBL3827187 | — | — | 1 | 6.86 |
| CHEMBL3828555 | — | — | 1 | 6.76 |
| CHEMBL3827623 | — | — | 1 | 6.76 |
| CHEMBL3827301 | — | — | 1 | 6.76 |
| CHEMBL3827267 | — | — | 1 | 6.75 |
| CHEMBL3828002 | — | — | 1 | 6.74 |
| CHEMBL3827298 | — | — | 1 | 6.59 |
| CHEMBL3827922 | — | — | 1 | 6.57 |
| CHEMBL3827716 | — | — | 1 | 6.53 |
| CHEMBL3828401 | — | — | 1 | 6.46 |
| CHEMBL3828658 | — | — | 1 | 6.43 |
| CHEMBL3827653 | — | — | 1 | 6.25 |
| CHEMBL3827216 | — | — | 1 | 5.86 |
| CHEMBL3827628 | — | — | 1 | 5.76 |
| CHEMBL3827973 | — | — | 1 | - |
| CHEMBL3828530 | — | — | 1 | - |
| CHEMBL3828477 | — | — | 1 | - |
| CHEMBL3828341 | — | — | 1 | - |
| CHEMBL3827127 | — | — | 1 | - |
| CHEMBL3827704 | — | — | 1 | - |
| CHEMBL3093326 | — | — | 1 | - |
| CHEMBL3827031 | — | — | 1 | - |
| CHEMBL3828044 | — | — | 1 | - |
| CHEMBL3827075 | — | — | 1 | - |
| CHEMBL3828237 | — | — | 1 | - |
| CHEMBL3827920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827598 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL3827074 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL3827331 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL3827201 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL3827187 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL3828555 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL3827623 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL3827301 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL3827267 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3828002 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL3827298 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL3827922 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL3827716 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL3828401 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL3828658 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL3827653 | — | Ki | = | 567.0 | nM | 6.25 |
| CHEMBL3827216 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL3827628 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL3827859 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827544 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3828343 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827016 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827583 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827175 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827365 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827920 | — | Ki | > | 500.0 | nM | - |
| CHEMBL3828237 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827075 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3828044 | — | Ki | > | 500.0 | nM | - |
| CHEMBL3827031 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093326 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827704 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827127 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3828341 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3828477 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3828530 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3827973 | — | Ki | > | 1000.0 | nM | - |