Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3853546

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of URAT1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Solute carrier family 22 member 12 (CHEMBL6120)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Medchemcomm (2016) 7 : 1587 -1595
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 6.05 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388590 BENZBROMARONE 4.0 1 7.66
CHEMBL3707347 VERINURAD 2.0 1 7.64
CHEMBL2105720 LESINURAD 4.0 1 5.17
CHEMBL981 FENOFIBRIC ACID 4.0 1 4.96
CHEMBL897 PROBENECID 4.0 1 4.82
CHEMBL672 FENOFIBRATE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388590 BENZBROMARONE IC50 = 22.0 nM 7.66
CHEMBL3707347 VERINURAD IC50 = 23.0 nM 7.64
CHEMBL2105720 LESINURAD IC50 = 6700.0 nM 5.17
CHEMBL981 FENOFIBRIC ACID IC50 = 11000.0 nM 4.96
CHEMBL897 PROBENECID IC50 = 15000.0 nM 4.82
CHEMBL672 FENOFIBRATE IC50 > 75000.0 nM -