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Assay Detail

CHEMBL3853552

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human C-terminal eGFP-tagged URAT1 long isoform expressed in CHO cells assessed as decrease in [14C]-uric acid uptake preincubated for 15 mins followed by [14C]-uric acid addition and incubated in dark for 3 hrs by scintillation counting method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Solute carrier family 22 member 12 (CHEMBL6120)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Medchemcomm (2016) 7 : 1572 -1579
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 6.85 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3971610 1 8.15
CHEMBL3899557 1 7.75
CHEMBL3902309 1 7.75
CHEMBL3947681 1 7.70
CHEMBL3978281 1 7.64
CHEMBL3900479 1 7.54
CHEMBL3973326 1 7.50
CHEMBL3984949 1 7.46
CHEMBL3929544 1 7.44
CHEMBL3979882 1 7.41
CHEMBL3924161 1 7.38
CHEMBL3950939 1 7.15
CHEMBL3933221 1 7.09
CHEMBL3960689 1 7.09
CHEMBL3892944 1 7.05
CHEMBL3971816 1 7.05
CHEMBL3890592 1 6.96
CHEMBL3944865 1 6.92
CHEMBL3938886 1 6.90
CHEMBL3920396 1 6.81
CHEMBL3965811 1 6.78
CHEMBL3942205 1 6.74
CHEMBL3923480 1 6.73
CHEMBL3983987 1 6.73
CHEMBL3919891 1 6.70
CHEMBL3893319 1 6.32
CHEMBL3935920 1 6.21
CHEMBL3915151 1 5.99
CHEMBL3920960 1 5.93
CHEMBL3962348 1 5.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3971610 IC50 = 7.0 nM 8.15
CHEMBL3899557 IC50 = 18.0 nM 7.75
CHEMBL3902309 IC50 = 18.0 nM 7.75
CHEMBL3947681 IC50 = 20.0 nM 7.70
CHEMBL3978281 IC50 = 23.0 nM 7.64
CHEMBL3900479 IC50 = 29.0 nM 7.54
CHEMBL3973326 IC50 = 32.0 nM 7.50
CHEMBL3984949 IC50 = 35.0 nM 7.46
CHEMBL3929544 IC50 = 36.0 nM 7.44
CHEMBL3979882 IC50 = 39.0 nM 7.41
CHEMBL3924161 IC50 = 42.0 nM 7.38
CHEMBL3950939 IC50 = 71.0 nM 7.15
CHEMBL3933221 IC50 = 81.0 nM 7.09
CHEMBL3960689 IC50 = 81.0 nM 7.09
CHEMBL3971816 IC50 = 89.0 nM 7.05
CHEMBL3892944 IC50 = 89.0 nM 7.05
CHEMBL3890592 IC50 = 111.0 nM 6.96
CHEMBL3944865 IC50 = 119.0 nM 6.92
CHEMBL3938886 IC50 = 127.0 nM 6.90
CHEMBL3920396 IC50 = 156.0 nM 6.81
CHEMBL3965811 IC50 = 166.0 nM 6.78
CHEMBL3942205 IC50 = 183.0 nM 6.74
CHEMBL3923480 IC50 = 187.0 nM 6.73
CHEMBL3983987 IC50 = 185.0 nM 6.73
CHEMBL3919891 IC50 = 199.0 nM 6.70
CHEMBL3893319 IC50 = 484.0 nM 6.32
CHEMBL3935920 IC50 = 616.0 nM 6.21
CHEMBL3915151 IC50 = 1030.0 nM 5.99
CHEMBL3920960 IC50 = 1170.0 nM 5.93
CHEMBL3962348 IC50 = 1480.0 nM 5.83
CHEMBL3953588 IC50 = 1970.0 nM 5.71
CHEMBL3955827 IC50 = 1970.0 nM 5.71
CHEMBL3902419 IC50 = 3610.0 nM 5.44
CHEMBL3901925 IC50 = 3920.0 nM 5.41
CHEMBL3929868 IC50 > 10000.0 nM -
CHEMBL3955343 IC50 > 10000.0 nM -