Assay Detail
Binding
CHEMBL3853646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at DAT in rat synaptosomes obtained from striatum assessed as release of [3H]MPP+ by liquid scintillation counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.47 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471839 | — | — | 1 | 7.90 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 7.61 |
| CHEMBL3921422 | — | — | 1 | 6.69 |
| CHEMBL3982376 | — | — | 1 | 6.57 |
| CHEMBL3963971 | — | — | 1 | 6.52 |
| CHEMBL3974905 | — | — | 1 | 6.35 |
| CHEMBL3913053 | — | — | 1 | 6.27 |
| CHEMBL3912463 | — | — | 1 | 6.18 |
| CHEMBL3933915 | — | — | 1 | 6.18 |
| CHEMBL3930376 | — | — | 1 | 6.05 |
| CHEMBL3945529 | — | — | 1 | 6.00 |
| CHEMBL3965276 | — | — | 1 | 5.95 |
| CHEMBL3896023 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471839 | — | EC50 | = | 12.6 | nM | 7.90 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 24.8 | nM | 7.61 |
| CHEMBL3921422 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL3982376 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL3963971 | — | EC50 | = | 304.0 | nM | 6.52 |
| CHEMBL3974905 | — | EC50 | = | 443.0 | nM | 6.35 |
| CHEMBL3913053 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3912463 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3933915 | — | EC50 | = | 666.0 | nM | 6.18 |
| CHEMBL3930376 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3945529 | — | EC50 | = | 997.0 | nM | 6.00 |
| CHEMBL3965276 | — | EC50 | = | 1114.0 | nM | 5.95 |
| CHEMBL3896023 | — | EC50 | = | 1416.0 | nM | 5.85 |