Assay Detail
Toxicity
CHEMBL3853670
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Cytotoxicity against human SH-SY5Y cells assessed as decrease in cell viability after 24 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiosemicarbazone modification of 3-acetyl coumarin inhibits Aβ peptide aggregation and protect against Aβ-induced cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.12 | 4.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149463 | 3-ACETYLCOUMARIN | — | 1 | 4.12 |
| CHEMBL3952071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149463 | 3-ACETYLCOUMARIN | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3952071 | — | IC50 | <= | 185000.0 | nM | - |