Assay Detail
Binding
CHEMBL3854072
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Inhibition of Influenza A virus A/PR/8/34 RNA-dependent-RNA polymerase transfected in HEK293T cells assessed as reduction in viral growth after 24 hrs by minireplicon assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.63 | 4.75 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288047 | — | — | 2 | 4.75 |
| CHEMBL3288048 | — | — | 2 | 4.51 |
| CHEMBL3945111 | — | — | 2 | - |
| CHEMBL3577796 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288047 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3288048 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3288047 | — | Inhibition | - | % | - | |
| CHEMBL3945111 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3945111 | — | Inhibition | - | % | - | |
| CHEMBL3288048 | — | Inhibition | - | % | - | |
| CHEMBL3577796 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3577796 | — | Inhibition | - | % | - |