Assay Detail
Functional
CHEMBL3854201
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Cytotoxicity against human HCT116 cells measured after 18 hrs under hypoxic condition by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.01 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459120 | (+)-DISCORHABDIN B | — | 1 | 5.51 |
| CHEMBL1194747 | — | — | 1 | 5.21 |
| CHEMBL509890 | MAKALUVAMINE F | — | 1 | 5.14 |
| CHEMBL3920971 | — | — | 1 | 5.07 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 4.14 |
| CHEMBL3910426 | — | — | 1 | - |
| CHEMBL3912024 | — | — | 1 | - |
| CHEMBL3938903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459120 | (+)-DISCORHABDIN B | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1194747 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL509890 | MAKALUVAMINE F | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3920971 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 72700.0 | nM | 4.14 |
| CHEMBL3910426 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3912024 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3938903 | — | IC50 | > | 10000.0 | nM | - |