Assay Detail
Binding
CHEMBL3854639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DNA polymerase eta expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at 2 to 6 mins by reporter-strand displacement assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.17 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 7.21 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 75.0 | nM | 7.12 |