DNA polymerase eta · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q9Y253. Use UniProt Q9Y253 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y253 as the stable identity anchor, then attach disease evidence before program review.
DNA polymerase eta
Review this target as DNA polymerase eta, mapped to UniProt Q9Y253. Sequence length is 713 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA polymerase eta as ChEMBL target CHEMBL5542, mapped to UniProt Q9Y253. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA polymerase eta is the right protein anchor across sources, using UniProt Q9Y253 as the stable mapping.
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| Preferred Name | DNA polymerase eta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y253 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA polymerase eta |
| UniProt Accession | Q9Y253 |
| Component Type | Protein |
| Sequence Length | 713 aa |
DNA polymerase eta
Review this target as DNA polymerase eta, mapped to UniProt Q9Y253. Sequence length is 713 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6246 | 7.21 | IC50 | 62.0 | Clinical |
| CHEMBL275938 | 7.12 | IC50 | 75.0 | Preclinical |
| CHEMBL457821 | 5.3 | IC50 | 5000.0 | Preclinical |
| CHEMBL1917196 | 5.16 | IC50 | 6900.0 | Preclinical |
| CHEMBL5398631 | 5.11 | IC50 | 7700.0 | Preclinical |
| CHEMBL5433463 | 5.1 | IC50 | 8000.0 | Preclinical |
| CHEMBL1917198 | 5.08 | IC50 | 8400.0 | Preclinical |
| CHEMBL243677 | 5.06 | IC50 | 8700.0 | Preclinical |
| CHEMBL1277701 | 4.99 | IC50 | 10200.0 | Preclinical |
| CHEMBL163316 | 4.97 | IC50 | 10800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 28 | 5.0 |
| single protein format | 8 | 4 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |