Compound Detail
CHEMBL5433463
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5433463 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YNPDEEPROJUWCY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
445.9
MW (Da)
4.41
ALogP
4
HBA
2
HBD
63.1
PSA (Ų)
0.28
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA polymerase eta CHEMBL5542 | IC50 | 5.1 | 5.1 | 8000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA polymerase eta | IC50 | = | 8000.0 | nM | 5.1 | Inhibition of human DNA polymerase eta (1 to 437 residues) using 5'-TTT TTT TTG ... | 36621139 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36621139 | 10.1016/j.ejmech.2022.115044 | DNA polymerase eta | 1 |
Data from ChEMBL 36 via Core Engine