Assay Detail
Binding
CHEMBL3854641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions preincubated for 15 mins followed by DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.25 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463914 | MANOALIDE | — | 1 | 5.25 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | 4.0 | 1 | 5.25 |
| CHEMBL3960997 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463914 | MANOALIDE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3960997 | — | IC50 | = | 5600.0 | nM | 5.25 |