Assay Detail
Binding
CHEMBL3854645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His6-tagged human DNA polymerase eta (1 to 511 residues) expressed in Escherichia coli using poly(dA)/oligo(dT)18 and [3H]dTTP as template-primer and nucleotide substrate after 60 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593571 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593571 | — | IC50 | = | 50000.0 | nM | 4.30 |