Assay Detail
Binding
CHEMBL3854650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 (CHEMBL3430885) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.27 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1423 | PIMOZIDE | 4.0 | 1 | 5.70 |
| CHEMBL21241 | GW7647 | — | 1 | 5.30 |
| CHEMBL6066864 | FLUPENTIXOL | 3.0 | 1 | 5.16 |
| CHEMBL34241 | ROTTLERIN | — | 1 | 5.10 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1423 | PIMOZIDE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL21241 | GW7647 | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6066864 | FLUPENTIXOL | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL34241 | ROTTLERIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 8000.0 | nM | 5.10 |