Assay Detail
Binding
CHEMBL3854655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human factor 10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.53 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3935309 | — | — | 1 | 6.00 |
| CHEMBL3891120 | — | — | 1 | 5.75 |
| CHEMBL3951940 | — | — | 1 | 5.70 |
| CHEMBL3942944 | — | — | 1 | 5.60 |
| CHEMBL3980787 | — | — | 1 | 5.41 |
| CHEMBL3902498 | — | — | 1 | 5.40 |
| CHEMBL3917434 | — | — | 1 | 5.37 |
| CHEMBL3978562 | — | — | 1 | 5.32 |
| CHEMBL3930523 | — | — | 1 | 5.21 |
| CHEMBL3926417 | — | — | 1 | - |
| CHEMBL3907376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3935309 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3891120 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3951940 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3942944 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL3980787 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL3902498 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3917434 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL3978562 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL3930523 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL3926417 | — | Ki | > | 9000.0 | nM | - |
| CHEMBL3907376 | — | Ki | > | 10000.0 | nM | - |