Assay Detail
Binding
CHEMBL3854656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human factor 11a using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.40 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3978562 | — | — | 1 | 5.85 |
| CHEMBL3891120 | — | — | 1 | 5.64 |
| CHEMBL3980787 | — | — | 1 | 5.54 |
| CHEMBL3951940 | — | — | 1 | 5.51 |
| CHEMBL3902498 | — | — | 1 | 5.47 |
| CHEMBL3917434 | — | — | 1 | 5.21 |
| CHEMBL3926417 | — | — | 1 | 5.19 |
| CHEMBL3942944 | — | — | 1 | 5.15 |
| CHEMBL3935309 | — | — | 1 | 5.06 |
| CHEMBL3930523 | — | — | 1 | - |
| CHEMBL3907376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3978562 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3891120 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3980787 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL3951940 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL3902498 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL3917434 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL3926417 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL3942944 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL3935309 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL3930523 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3907376 | — | Ki | > | 10000.0 | nM | - |