Assay Detail
Functional
CHEMBL3855225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B harboring reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.46 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3929927 | — | — | 1 | 8.54 |
| CHEMBL3968659 | — | — | 1 | 8.35 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.28 |
| CHEMBL3978123 | — | — | 1 | 8.19 |
| CHEMBL3982017 | — | — | 1 | 8.18 |
| CHEMBL3957618 | — | — | 1 | 8.16 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.14 |
| CHEMBL3906493 | — | — | 1 | 8.06 |
| CHEMBL3937883 | — | — | 1 | 7.86 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.84 |
| CHEMBL3934629 | — | — | 1 | 7.74 |
| CHEMBL3898380 | — | — | 1 | 7.68 |
| CHEMBL3953578 | — | — | 1 | 7.66 |
| CHEMBL3895179 | — | — | 1 | 7.46 |
| CHEMBL3957481 | — | — | 1 | 7.41 |
| CHEMBL3941247 | — | — | 1 | 7.40 |
| CHEMBL3966489 | — | — | 1 | 7.38 |
| CHEMBL3902362 | — | — | 1 | 7.29 |
| CHEMBL3893309 | — | — | 1 | 7.29 |
| CHEMBL3987144 | — | — | 1 | 6.90 |
| CHEMBL3935488 | — | — | 1 | 6.78 |
| CHEMBL3895855 | — | — | 1 | 6.76 |
| CHEMBL3914832 | — | — | 1 | 6.76 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.57 |
| CHEMBL3943215 | — | — | 1 | 5.99 |
| CHEMBL3963461 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3929927 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3968659 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3978123 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3982017 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3957618 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3906493 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3937883 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL3934629 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL3898380 | — | EC50 | = | 20.9 | nM | 7.68 |
| CHEMBL3953578 | — | EC50 | = | 21.9 | nM | 7.66 |
| CHEMBL3895179 | — | EC50 | = | 34.4 | nM | 7.46 |
| CHEMBL3957481 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3941247 | — | EC50 | = | 39.5 | nM | 7.40 |
| CHEMBL3966489 | — | EC50 | = | 42.2 | nM | 7.38 |
| CHEMBL3902362 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3893309 | — | EC50 | = | 50.9 | nM | 7.29 |
| CHEMBL3987144 | — | EC50 | = | 125.9 | nM | 6.90 |
| CHEMBL3935488 | — | EC50 | = | 166.1 | nM | 6.78 |
| CHEMBL3895855 | — | EC50 | = | 172.0 | nM | 6.76 |
| CHEMBL3914832 | — | EC50 | = | 174.0 | nM | 6.76 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 271.0 | nM | 6.57 |
| CHEMBL3943215 | — | EC50 | = | 1019.0 | nM | 5.99 |
| CHEMBL3963461 | — | EC50 | = | 5505.0 | nM | 5.26 |