Assay Detail
Binding
CHEMBL3855495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degC
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Coagulation factor VII/tissue factor (CHEMBL2095194) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.18 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3956096 | — | — | 1 | 10.22 |
| CHEMBL3900166 | — | — | 1 | 9.85 |
| CHEMBL3984725 | — | — | 1 | 9.66 |
| CHEMBL3898371 | — | — | 1 | 9.26 |
| CHEMBL3967204 | — | — | 1 | 9.14 |
| CHEMBL3895930 | — | — | 1 | 8.36 |
| CHEMBL3934882 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3956096 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL3900166 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3984725 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3898371 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL3967204 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL3895930 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3934882 | — | Ki | = | 18.0 | nM | 7.75 |