Assay Detail
Binding
CHEMBL3855496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of factor 10a (unknown origin) at 25 degC by chromogenic substrate assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.77 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3900166 | — | — | 1 | 6.07 |
| CHEMBL3956096 | — | — | 1 | 6.05 |
| CHEMBL3967204 | — | — | 1 | 5.98 |
| CHEMBL3895930 | — | — | 1 | 5.85 |
| CHEMBL3984725 | — | — | 1 | 5.75 |
| CHEMBL3934882 | — | — | 1 | 5.52 |
| CHEMBL3898371 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3900166 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL3956096 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL3967204 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL3895930 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3984725 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3934882 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3898371 | — | Ki | = | 6650.0 | nM | 5.18 |