Assay Detail
Binding
CHEMBL3855500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.54 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3898371 | — | — | 1 | 7.16 |
| CHEMBL3956096 | — | — | 1 | 6.81 |
| CHEMBL3967204 | — | — | 1 | 6.76 |
| CHEMBL3934882 | — | — | 1 | 6.66 |
| CHEMBL3984725 | — | — | 1 | 6.47 |
| CHEMBL3900166 | — | — | 1 | 6.14 |
| CHEMBL3895930 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3898371 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3956096 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL3967204 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL3934882 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3984725 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL3900166 | — | Ki | = | 725.0 | nM | 6.14 |
| CHEMBL3895930 | — | Ki | = | 1600.0 | nM | 5.80 |