Assay Detail
Binding
CHEMBL3855510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TF-factor 7a (366 to 11 residues) using factor 10 as substrate after 60 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Coagulation factor VII/tissue factor (CHEMBL2095194) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.25 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3891120 | — | — | 1 | 9.80 |
| CHEMBL3976650 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3891120 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL3976650 | — | Ki | = | 2.0 | nM | 8.70 |