Assay Detail
Functional
CHEMBL3855698
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Cytotoxicity against human NCI-H2009 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2009 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.57 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3910864 | — | — | 1 | 5.85 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 5.80 |
| CHEMBL3967383 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3910864 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3967383 | — | IC50 | = | 8900.0 | nM | 5.05 |