Assay Detail
Functional
CHEMBL3855920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against patient-derived IgM-stimulated CLL cells after 3 days by CellTiter-Glo assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CLL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.52 | 5.52 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3942643 | — | — | 2 | 5.52 |
| CHEMBL3959351 | — | — | 1 | - |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | - |
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3942643 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3959351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2216870 | IDELALISIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL3039502 | DUVELISIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL3942643 | — | Activity | - | — | - |