Assay Detail
Binding
CHEMBL3855949
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Displacement of [3H]-RX 821002 from alpha2-AR in Sprague-Dawley rat brain membranes after 30 mins by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.12 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3904276 | — | — | 1 | 7.73 |
| CHEMBL51358 | — | — | 1 | 7.59 |
| CHEMBL3961335 | — | — | 1 | 6.79 |
| CHEMBL3892351 | — | — | 1 | 6.75 |
| CHEMBL337862 | — | — | 1 | 6.75 |
| CHEMBL1439667 | — | — | 1 | - |
| CHEMBL3920069 | — | — | 1 | - |
| CHEMBL3939078 | — | — | 1 | - |
| CHEMBL3911124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3904276 | — | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL51358 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL3961335 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL3892351 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL337862 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL1439667 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3920069 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3939078 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3911124 | — | Ki | > | 1000.0 | nM | - |