Assay Detail
Binding
CHEMBL3855953
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Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.71 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51358 | — | — | 1 | 6.11 |
| CHEMBL337862 | — | — | 1 | 6.02 |
| CHEMBL3961335 | — | — | 1 | 5.60 |
| CHEMBL3904276 | — | — | 1 | 5.50 |
| CHEMBL3892351 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51358 | — | EC50 | = | 776.25 | nM | 6.11 |
| CHEMBL337862 | — | EC50 | = | 954.99 | nM | 6.02 |
| CHEMBL3961335 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL3904276 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL3892351 | — | EC50 | = | 4570.88 | nM | 5.34 |