Assay Detail
Binding
CHEMBL3856320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal 6His-tagged SIRT2 assessed as inhibition of deacetylase activity using ZMAL as substrate measured after 4 hrs by Fluor de Lys assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.06 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795371 | — | — | 1 | 5.06 |
| CHEMBL3920465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795371 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3920465 | — | IC50 | < | 20300.0 | nM | - |