Assay Detail
Functional
CHEMBL3856359
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Antiviral activity against Influenza A virus A/Thailand/Kan353/2004(H5N1) pseudovirus infected in MDCK cells co-infected with HA/HIV assessed as inhibition of viral replication preincubated with virus for 30 mins followed by viral infection for 48 hrs by luciferase based plaque reduction assay
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Thailand/Kan353/2004(H5N1)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of 3-O-β-chacotriosyl oleanane-type triterpenoids as potential H5N1 entry inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.29 | 5.63 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3971731 | — | — | 2 | 5.63 |
| CHEMBL3900582 | — | — | 1 | 5.61 |
| CHEMBL3415418 | — | — | 1 | 5.39 |
| CHEMBL2088468 | — | — | 1 | 5.35 |
| CHEMBL585172 | — | — | 1 | 5.32 |
| CHEMBL3929365 | — | — | 1 | 5.32 |
| CHEMBL3951913 | — | — | 1 | 5.28 |
| CHEMBL3976488 | — | — | 1 | 5.28 |
| CHEMBL3902325 | — | — | 1 | 5.25 |
| CHEMBL3947196 | — | — | 1 | 5.24 |
| CHEMBL3980764 | — | — | 1 | 5.19 |
| CHEMBL574686 | — | — | 1 | 5.10 |
| CHEMBL3955932 | — | — | 1 | 5.07 |
| CHEMBL3943169 | — | — | 1 | 5.03 |
| CHEMBL3984557 | — | — | 1 | - |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3971731 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL3900582 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL3415418 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2088468 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL585172 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL3929365 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3951913 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3976488 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL3902325 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL3947196 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3980764 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL574686 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL3955932 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL3943169 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL3984557 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3971731 | — | Inhibition | - | % | - |