Assay Detail
Binding
CHEMBL3856469
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Inhibition of CDK9/cyclin T (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.62 | 7.66 |
| Ki | 1 | 7.24 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3905910 | VORUCICLIB | 2.0 | 1 | 7.66 |
| CHEMBL3655762 | CYC-065 | 2.0 | 1 | 7.58 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 7.24 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3905910 | VORUCICLIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3655762 | CYC-065 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3301610 | ABEMACICLIB | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL445813 | AT-7519 | IC50 | < | 10.0 | nM | - |