Assay Detail
Binding
CHEMBL3856474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length C-terminal His6-tagged CDK9/cyclin T1 expressed in baculovirus infected Sf21 insect cells using PDKtide as substrate
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.22 | 8.40 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 8.40 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.30 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.96 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296468 | BMS-387032 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL445813 | AT-7519 | Ki | < | 100.0 | nM | - |