Assay Detail
Binding
CHEMBL3856498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human His6-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using GST-CTD as substrate after 10 mins in presence of [gamma-32P]ATP by SDS-PAGE analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.23 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3896233 | — | — | 1 | 8.68 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 8.60 |
| CHEMBL3924246 | — | — | 1 | 8.55 |
| CHEMBL3915260 | — | — | 1 | 8.26 |
| CHEMBL3976972 | — | — | 1 | 8.19 |
| CHEMBL3898028 | — | — | 1 | 8.05 |
| CHEMBL3906282 | — | — | 1 | 8.02 |
| CHEMBL3985045 | — | — | 1 | 8.02 |
| CHEMBL3897316 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3896233 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3924246 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3915260 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3976972 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3898028 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3906282 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3985045 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3897316 | — | IC50 | = | 19.0 | nM | 7.72 |