Assay Detail
Binding
CHEMBL3856829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of recombinant Coxsackievirus B3 3C protease expressed in Escherichia coli BL21 (DE3) preincubated with protein followed by addition of NMA-EALFQGPPVK-DNP-rrr-NH2 as substrate measured every 5 mins for 2 hrs by Dixon plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Coxsackievirus B3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Genome polyprotein (CHEMBL2396505) ↗| Type | SINGLE PROTEIN |
| Organism | Coxsackievirus B3 (strain Nancy) |
Publication
2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 6.49 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3968123 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3968123 | — | Ki | = | 324.0 | nM | 6.49 |