Assay Detail
Binding
CHEMBL3857034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus by Z'-LYTE assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.12 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3901622 | — | — | 1 | 9.40 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 9.40 |
| CHEMBL3891846 | — | — | 1 | 9.22 |
| CHEMBL3960853 | — | — | 1 | 8.96 |
| CHEMBL3919609 | — | — | 1 | 8.82 |
| CHEMBL3928512 | — | — | 1 | 8.70 |
| CHEMBL3961553 | — | — | 1 | 8.70 |
| CHEMBL3952157 | — | — | 1 | 8.57 |
| CHEMBL3892567 | — | — | 1 | 8.41 |
| CHEMBL3961961 | — | — | 1 | 8.40 |
| CHEMBL3947406 | — | — | 1 | 8.40 |
| CHEMBL3956112 | — | — | 1 | 8.34 |
| CHEMBL3933539 | — | — | 1 | 8.28 |
| CHEMBL3946396 | — | — | 1 | 8.15 |
| CHEMBL3908303 | — | — | 1 | 7.96 |
| CHEMBL3967219 | — | — | 1 | 7.89 |
| CHEMBL3943438 | — | — | 1 | 7.85 |
| CHEMBL3934461 | — | — | 1 | 7.66 |
| CHEMBL3972981 | — | — | 1 | 7.66 |
| CHEMBL3925584 | — | — | 1 | 7.62 |
| CHEMBL3953210 | — | — | 1 | 7.62 |
| CHEMBL3973601 | — | — | 1 | 7.57 |
| CHEMBL3952877 | — | — | 1 | 7.55 |
| CHEMBL3929584 | — | — | 1 | 7.54 |
| CHEMBL3975699 | — | — | 1 | 7.36 |
| CHEMBL3937527 | — | — | 1 | 7.25 |
| CHEMBL3939429 | — | — | 1 | 7.13 |
| CHEMBL3981621 | — | — | 1 | 7.03 |
| CHEMBL3944121 | — | — | 1 | - |
| CHEMBL3962640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3901622 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3891846 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3960853 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3919609 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3928512 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3961553 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3952157 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3892567 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3961961 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3947406 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3956112 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3933539 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3946396 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3908303 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3967219 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3943438 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3934461 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3972981 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3925584 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3953210 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3973601 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3952877 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3929584 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3975699 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3937527 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3939429 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3981621 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3944121 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3962640 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3935149 | — | IC50 | > | 1000.0 | nM | - |