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Assay Detail

CHEMBL3857941

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at rat beta1 adrenoceptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-1 adrenergic receptor (CHEMBL3252)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
Talele TT.
J Med Chem (2016) 59 : 8712 -8756
PubMed 27299736 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 8.09 8.53

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL423 BETAXOLOL 4.0 1 8.53
CHEMBL13 METOPROLOL 4.0 1 7.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL423 BETAXOLOL Kd = 2.951 nM 8.53
CHEMBL13 METOPROLOL Kd = 22.91 nM 7.64