Assay Detail

CHEMBL3858963

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of BMX (unknown origin)

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Cytoplasmic tyrosine-protein kinase BMX (CHEMBL3834) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Cytoplasmic tyrosine-protein kinase BMX (CHEMBL3834) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytoplasmic tyrosine-protein kinase BMX

CHEMBL3834

Anchored from Assay target.

Protein identity Cytoplasmic tyrosine-protein kinase BMX

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytoplasmic tyrosine-protein kinase BMX (CHEMBL3834) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.

Watterson SH, De Lucca GV, Shi Q, Langevine CM, Liu Q, Batt DG, Beaudoin Bertrand M, Gong H, Dai J, Yip S, Li P, Sun D, Wu DR, Wang C, Zhang Y, Traeger SC, Pattoli MA, Skala S, Cheng L, Obermeier MT, Vickery R, Discenza LN, D'Arienzo CJ, Zhang Y, Heimrich E, Gillooly KM, Taylor TL, Pulicicchio C, McIntyre KW, Galella MA, Tebben AJ, Muckelbauer JK, Chang C, Rampulla R, Mathur A, Salter-Cid L, Barrish JC, Carter PH, Fura A, Burke JR, Tino JA.
J Med Chem (2016) 59 : 9173 -9200
PubMed 27583770 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.50	7.50

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3900554	BMS-986142	2.0	1	7.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3900554	BMS-986142	IC50	=	32.0	nM	7.50