Assay Detail
Toxicity
CHEMBL3859147
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Cytotoxicity against rat L6 cells after 6 days by resazurin based fluorescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.99 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3908171 | — | — | 1 | 5.62 |
| CHEMBL3961773 | — | — | 1 | 5.42 |
| CHEMBL3944432 | — | — | 1 | 5.37 |
| CHEMBL3939732 | — | — | 1 | 5.36 |
| CHEMBL3910753 | — | — | 1 | 5.32 |
| CHEMBL3892765 | — | — | 1 | 5.32 |
| CHEMBL3953051 | — | — | 1 | 5.30 |
| CHEMBL3981921 | — | — | 1 | 5.24 |
| CHEMBL1083789 | — | — | 1 | 5.14 |
| CHEMBL2393095 | — | — | 1 | 5.12 |
| CHEMBL3901727 | — | — | 1 | 5.12 |
| CHEMBL3972196 | — | — | 1 | 5.12 |
| CHEMBL3902953 | — | — | 1 | 5.10 |
| CHEMBL3905154 | — | — | 1 | 5.09 |
| CHEMBL3980826 | — | — | 1 | 5.09 |
| CHEMBL3981794 | — | — | 1 | 5.00 |
| CHEMBL3910120 | — | — | 1 | 4.96 |
| CHEMBL3972808 | — | — | 1 | 4.94 |
| CHEMBL3906380 | — | — | 1 | 4.92 |
| CHEMBL3937637 | — | — | 1 | 4.90 |
| CHEMBL3901071 | — | — | 1 | 4.87 |
| CHEMBL3985938 | — | — | 1 | 4.84 |
| CHEMBL3945505 | — | — | 1 | 4.80 |
| CHEMBL1083790 | — | — | 1 | 4.78 |
| CHEMBL3970941 | — | — | 1 | 4.72 |
| CHEMBL3941365 | — | — | 1 | 4.69 |
| CHEMBL3890983 | — | — | 1 | 4.68 |
| CHEMBL3973917 | — | — | 1 | 4.56 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 4.50 |
| CHEMBL3911974 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3908171 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3961773 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL3944432 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL3939732 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL3910753 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL3892765 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL3953051 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL3981921 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL1083789 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL2393095 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL3901727 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL3972196 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL3902953 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3905154 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL3980826 | — | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL3981794 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3910120 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL3972808 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3906380 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3937637 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3901071 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3985938 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3945505 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL1083790 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL3970941 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3941365 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3890983 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3973917 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3911974 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL3909021 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL3977576 | — | IC50 | < | 1200.0 | nM | - |