Assay Detail
Functional
CHEMBL3859154
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Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of Hederacolchiside A1 derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.13 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3978037 | — | — | 1 | 5.89 |
| CHEMBL3889593 | — | — | 1 | 5.75 |
| CHEMBL3907513 | — | — | 1 | 5.57 |
| CHEMBL444941 | HEDERACOLCHISIDE A1 | — | 1 | 5.43 |
| CHEMBL3949913 | — | — | 1 | 5.08 |
| CHEMBL3932152 | — | — | 1 | 5.01 |
| CHEMBL3959663 | — | — | 1 | 4.85 |
| CHEMBL3911788 | — | — | 1 | 4.33 |
| CHEMBL3895292 | — | — | 1 | 4.25 |
| CHEMBL3936333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3978037 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3889593 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3907513 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL444941 | HEDERACOLCHISIDE A1 | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3949913 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3932152 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3959663 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3911788 | — | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL3895292 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL3936333 | — | IC50 | > | 100000.0 | nM | - |