Assay Detail
Binding
CHEMBL3859720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-FAM-Bid peptide binding to Bcl-XL (unknown origin) by fluorescence polarization assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.80 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 9.00 |
| CHEMBL3891088 | — | — | 1 | 7.16 |
| CHEMBL3980363 | — | — | 1 | 7.05 |
| CHEMBL3926515 | — | — | 1 | 6.96 |
| CHEMBL3933727 | — | — | 1 | 6.92 |
| CHEMBL3951428 | — | — | 1 | 6.89 |
| CHEMBL3900077 | — | — | 1 | 6.85 |
| CHEMBL3909131 | — | — | 1 | 6.80 |
| CHEMBL3971723 | — | — | 1 | 6.77 |
| CHEMBL3960206 | — | — | 1 | 6.68 |
| CHEMBL3979383 | — | — | 1 | 6.68 |
| CHEMBL3961198 | — | — | 1 | 6.54 |
| CHEMBL3902269 | — | — | 1 | 6.54 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.51 |
| CHEMBL3971226 | — | — | 1 | 6.50 |
| CHEMBL3947409 | — | — | 1 | 6.48 |
| CHEMBL3976674 | — | — | 1 | 6.35 |
| CHEMBL3960600 | — | — | 1 | 6.29 |
| CHEMBL1940668 | — | — | 1 | 6.20 |
| CHEMBL3918541 | — | — | 1 | - |
| CHEMBL3895790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3891088 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3980363 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3926515 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3933727 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3951428 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3900077 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3909131 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3971723 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL3960206 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3979383 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3961198 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3902269 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3971226 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL3947409 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL3976674 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3960600 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL1940668 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3918541 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL3895790 | — | Ki | > | 20000.0 | nM | - |