Assay Detail
Functional
CHEMBL3859765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 VSG 221 [TetR T7RNAP] transgenic bloodstream forms assessed as reduction in cell viability after 48 hrs by alamar blue assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 53 | 5.13 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.92 |
| CHEMBL3950773 | — | — | 1 | 5.75 |
| CHEMBL3934460 | — | — | 1 | 5.68 |
| CHEMBL3979736 | — | — | 1 | 5.62 |
| CHEMBL3978830 | — | — | 1 | 5.57 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.55 |
| CHEMBL3115908 | — | — | 1 | 5.51 |
| CHEMBL3975683 | — | — | 1 | 5.50 |
| CHEMBL3954893 | — | — | 1 | 5.48 |
| CHEMBL3947198 | — | — | 1 | 5.48 |
| CHEMBL3952406 | — | — | 1 | 5.43 |
| CHEMBL3908434 | — | — | 1 | 5.39 |
| CHEMBL3913878 | — | — | 1 | 5.37 |
| CHEMBL3904891 | — | — | 1 | 5.35 |
| CHEMBL3970551 | — | — | 1 | 5.32 |
| CHEMBL3890411 | — | — | 1 | 5.31 |
| CHEMBL3910488 | — | — | 1 | 5.30 |
| CHEMBL3919412 | — | — | 1 | 5.29 |
| CHEMBL3983712 | — | — | 1 | 5.23 |
| CHEMBL3903813 | — | — | 1 | 5.19 |
| CHEMBL3942054 | — | — | 1 | 5.10 |
| CHEMBL3938421 | — | — | 1 | 5.05 |
| CHEMBL3894879 | — | — | 1 | 5.00 |
| CHEMBL3928317 | — | — | 1 | 4.96 |
| CHEMBL3919336 | — | — | 1 | 4.89 |
| CHEMBL3966262 | — | — | 1 | 4.82 |
| CHEMBL3955935 | — | — | 1 | 4.82 |
| CHEMBL3906378 | — | — | 1 | 4.80 |
| CHEMBL3975456 | — | — | 1 | 4.77 |
| CHEMBL3937258 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3950773 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3934460 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3979736 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3978830 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3115908 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3975683 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3954893 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3947198 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3952406 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3908434 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3913878 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3904891 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3970551 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3890411 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3910488 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3919412 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3983712 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3903813 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3942054 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3938421 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3894879 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3928317 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3919336 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3966262 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3955935 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3906378 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3975456 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3937258 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3922861 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3986320 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3943318 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3915348 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3952045 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3951335 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3983061 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3960743 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3899371 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3934352 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3967047 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3894125 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3924724 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3933283 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3980253 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3912547 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3907505 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3924343 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL3978029 | — | EC50 | > | 42000.0 | nM | - |
| CHEMBL830 | EFLORNITHINE | EC50 | > | 42000.0 | nM | - |