Assay Detail
Binding
CHEMBL3859786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 5-FAM-ARTEVHLRKS binding to WDR5 (unknown origin) by fluorescence polarization assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.64 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3957478 | — | — | 1 | 7.58 |
| CHEMBL3907289 | — | — | 1 | 7.33 |
| CHEMBL3962459 | — | — | 1 | 7.23 |
| CHEMBL3913104 | — | — | 1 | 6.79 |
| CHEMBL3971604 | — | — | 1 | 6.61 |
| CHEMBL3903051 | — | — | 1 | 6.58 |
| CHEMBL3922104 | — | — | 1 | 6.55 |
| CHEMBL3942025 | — | — | 1 | 6.36 |
| CHEMBL3950744 | — | — | 1 | 6.34 |
| CHEMBL3904098 | — | — | 1 | 6.32 |
| CHEMBL3982971 | — | — | 1 | 6.09 |
| CHEMBL3894097 | — | — | 1 | 5.93 |
| CHEMBL3953704 | — | — | 1 | - |
| CHEMBL3906985 | — | — | 1 | - |
| CHEMBL3893446 | — | — | 1 | - |
| CHEMBL3965924 | — | — | 1 | - |
| CHEMBL3936042 | — | — | 1 | - |
| CHEMBL3956505 | — | — | 1 | - |
| CHEMBL3929919 | — | — | 1 | - |
| CHEMBL3943757 | — | — | 1 | - |
| CHEMBL3935228 | — | — | 1 | - |
| CHEMBL3938878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3957478 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL3907289 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL3962459 | — | IC50 | = | 58.8 | nM | 7.23 |
| CHEMBL3913104 | — | IC50 | = | 162.4 | nM | 6.79 |
| CHEMBL3971604 | — | IC50 | = | 244.9 | nM | 6.61 |
| CHEMBL3903051 | — | IC50 | = | 263.5 | nM | 6.58 |
| CHEMBL3922104 | — | IC50 | = | 283.9 | nM | 6.55 |
| CHEMBL3942025 | — | IC50 | = | 433.2 | nM | 6.36 |
| CHEMBL3950744 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL3904098 | — | IC50 | = | 483.5 | nM | 6.32 |
| CHEMBL3982971 | — | IC50 | = | 811.6 | nM | 6.09 |
| CHEMBL3894097 | — | IC50 | = | 1171.0 | nM | 5.93 |
| CHEMBL3953704 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3906985 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3893446 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3965924 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3936042 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3956505 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3929919 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3943757 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3935228 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3938878 | — | IC50 | > | 20.0 | nM | - |