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Target Snapshot

CHEMBL1075317 Target Snapshot

WD repeat-containing protein 5 · SINGLE PROTEIN · Homo sapiens

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2,159Compounds
194Assays
0Approved Drugs
2,312.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P61964. Use UniProt P61964 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P61964 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats WD repeat-containing protein 5 as ChEMBL target CHEMBL1075317, mapped to UniProt P61964. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
WD repeat-containing protein 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075317
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P61964
WD repeat-containing protein 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether WD repeat-containing protein 5 is the right protein anchor across sources, using UniProt P61964 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameWD repeat-containing protein 5
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP61964
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelWD repeat-containing protein 5
UniProt AccessionP61964
Component TypeProtein
Sequence Length334 aa

WD repeat-containing protein 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as WD repeat-containing protein 5, mapped to UniProt P61964. Sequence length is 334 aa.

Mapped IDP61964
Review nameWD repeat-containing protein 5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC50376.0
KI832.0
EC501.0
KD1,103.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5190556 10.7 Ki 0.02 Preclinical
CHEMBL5414839 10.7 Ki 0.02 Preclinical
CHEMBL5422217 10.7 Ki 0.02 Preclinical
CHEMBL5871401 10.7 Ki 0.02 Preclinical
CHEMBL5888524 10.7 Ki 0.02 Preclinical
CHEMBL5998450 10.68 Ki 0.021 Preclinical
CHEMBL5169425 10.66 Ki 0.022 Preclinical
CHEMBL4463486 10.64 Kd 0.023 Preclinical
CHEMBL5181314 10.64 Ki 0.023 Preclinical
CHEMBL5398730 10.64 Ki 0.023 Preclinical
Distribution

pChEMBL Value Distribution

60
5.0
57
5.5
85
6.0
117
6.5
136
7.0
211
7.5
339
8.0
365
8.5
236
9.0
101
9.5
pChEMBL
Assay Landscape

Assay Landscape

194
Total Assays
1,756
Tested Compounds
2
Assay Types
Binding — 191 assays, 1,756 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 85 116 7.7
single protein format 78 601 8.3
assay format 25 220 6.1
organism-based format 2 802 8.3
subcellular format 1 17 5.8
Functional — 3 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 1 10.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine