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Assay Detail

CHEMBL3859956

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HBV ayw1 infected in human HepG2(2.2.15) cells assessed as reduction in viral replication by measuring extracellular viral DNA copy number after 6 days by real-time qPCR method
ChEMBL ↗
34
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication.
Liu C, Dumbre SG, Pannecouque C, Huang C, Ptak RG, Murray MG, De Jonghe S, Herdewijn P.
J Med Chem (2016) 59 : 9513 -9531
PubMed 27748590 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 6.40 8.00
EC90 17 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3929721 — — 2 8.00
CHEMBL3905033 — — 2 8.00
CHEMBL141 LAMIVUDINE 4.0 2 8.00
CHEMBL3957285 — — 2 7.52
CHEMBL3986583 — — 2 6.60
CHEMBL3975813 — — 2 6.58
CHEMBL3957894 — — 2 6.55
CHEMBL3938729 — — 2 6.30
CHEMBL3976812 — — 2 4.40
CHEMBL3897765 — — 2 4.32
CHEMBL3971162 — — 2 4.10
CHEMBL3947534 — — 2 -
CHEMBL3948614 — — 2 -
CHEMBL3929283 — — 2 -
CHEMBL3940478 — — 2 -
CHEMBL3970033 — — 2 -
CHEMBL3968934 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3929721 — EC50 = 10.0 nM 8.00
CHEMBL141 LAMIVUDINE EC50 = 10.0 nM 8.00
CHEMBL3905033 — EC50 = 10.0 nM 8.00
CHEMBL3957285 — EC50 = 30.0 nM 7.52
CHEMBL3986583 — EC50 = 250.0 nM 6.60
CHEMBL3975813 — EC50 = 260.0 nM 6.58
CHEMBL3957894 — EC50 = 280.0 nM 6.55
CHEMBL3938729 — EC50 = 500.0 nM 6.30
CHEMBL3976812 — EC50 = 40200.0 nM 4.40
CHEMBL3897765 — EC50 = 47890.0 nM 4.32
CHEMBL3971162 — EC50 = 79580.0 nM 4.10
CHEMBL3971162 — EC90 > 100.0 uM -
CHEMBL3948614 — EC90 > 100.0 uM -
CHEMBL3947534 — EC90 > 100.0 uM -
CHEMBL3976812 — EC90 > 100.0 uM -
CHEMBL3938729 — EC90 > 100.0 uM -
CHEMBL3968934 — EC50 > 100000.0 nM -
CHEMBL3970033 — EC50 > 100000.0 nM -
CHEMBL3940478 — EC50 > 100000.0 nM -
CHEMBL3929283 — EC50 > 100000.0 nM -
CHEMBL3947534 — EC50 > 100000.0 nM -
CHEMBL3948614 — EC50 > 100000.0 nM -
CHEMBL3957285 — EC90 > 10.0 uM -
CHEMBL3929283 — EC90 > 100.0 uM -
CHEMBL3940478 — EC90 > 100.0 uM -
CHEMBL3970033 — EC90 > 100.0 uM -
CHEMBL3968934 — EC90 > 100.0 uM -
CHEMBL3897765 — EC90 > 100.0 uM -
CHEMBL3957894 — EC90 > 10.0 uM -
CHEMBL3986583 — EC90 > 100.0 uM -
CHEMBL3975813 — EC90 > 10.0 uM -
CHEMBL3905033 — EC90 = 4.2 uM -
CHEMBL141 LAMIVUDINE EC90 > 2.0 uM -
CHEMBL3929721 — EC90 = 0.98 uM -