Assay Detail
Binding
CHEMBL3860146
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Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.94 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.00 |
| CHEMBL3818689 | — | — | 1 | 6.58 |
| CHEMBL3818089 | — | — | 1 | 6.41 |
| CHEMBL3905695 | — | — | 1 | 6.31 |
| CHEMBL3916769 | — | — | 1 | 6.20 |
| CHEMBL3818512 | — | — | 1 | 6.12 |
| CHEMBL3965783 | — | — | 1 | 6.00 |
| CHEMBL3819320 | — | — | 1 | 6.00 |
| CHEMBL3892044 | — | — | 1 | 5.95 |
| CHEMBL3818992 | — | — | 1 | 5.76 |
| CHEMBL3949439 | — | — | 1 | 5.46 |
| CHEMBL3917990 | — | — | 1 | 5.40 |
| CHEMBL3919086 | — | — | 1 | 5.33 |
| CHEMBL3978533 | — | — | 1 | 5.24 |
| CHEMBL3945872 | — | — | 1 | 5.22 |
| CHEMBL3936989 | — | — | 1 | 5.06 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
| CHEMBL153 | TROLOX | — | 1 | - |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3818689 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3818089 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3905695 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3916769 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3818512 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3965783 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3819320 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3892044 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3818992 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3949439 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL3917990 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3919086 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL3978533 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL3945872 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL3936989 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL972 | SELEGILINE | IC50 | - | — | - | |
| CHEMBL153 | TROLOX | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - |