Assay Detail
Functional
CHEMBL3860176
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Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UMUC3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.82 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551842 | LOBARIC ACID | — | 1 | 5.43 |
| CHEMBL368810 | — | — | 1 | 4.52 |
| CHEMBL171637 | PHYSODIC ACID | — | 1 | 4.50 |
| CHEMBL220486 | VARIOLARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551842 | LOBARIC ACID | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL368810 | — | EC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL171637 | PHYSODIC ACID | EC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL220486 | VARIOLARIC ACID | EC50 | > | 100000.0 | nM | - |